Ana Alimpic Faculty of Biology, University of Belgrade

Katarina Šavikin Institute for Medicinal Plant Research "Dr Josif Pančić", Belgrade

Dejan Pljevljakušić Institute for Medicinal Plant Research "Dr Josif Pančić", Belgrade

Vlado Matevski Faculty of Natural Sciences and Mathematics, University "Ss. Cyril and Methodius", Skopje

Petar D. Marin Faculty of Biology, University of Belgrade

Ivana Petrović Faculty of Agriculture, University of Belgrade

Sonja Duletić-Laušević Faculty of Biology, University of Belgrade

DOI: https://doi.org/10.7251/AGREN1701027A

Abstract

This research was aimed at investigating polyphenolic content, antioxidant and anti-neurodegenerative activities of post-distillation waste extracts of Macedonian Salvia amplexicaulis, S. jurisicii and S. ringens, for the first time. Total phenolic and flavonoid contents varied in a broad range (3.92-146.49 mg GAE/g and 7.11-67.51 mg QE/g, respectively), with the highest values obtained for S. amplexicaulis and S. ringens extracts. Certain S. amplexicaulis and S. ringens extracts neutralized more than 80% of DPPH radicals at the highest concentration, while S. amplexicaulis extracts showed up to ≈50% inhibition of β-carotene oxidation in β-carotene/linoleic acid assay. Post-distillation waste extracts inhibited acetylcholinesterase (25.94-38.15%) and tyrosinase (18.84-59.52%), with the strongest inhibition of S. amplexicaulis extracts. The obtained results suggest that post-distillation waste of tested species, especially of S. amplexicaulis, show antioxidant and anti-neurodegenerative activities and could be considered as potential raw material rich in polyphenols.